CELF3

更新于：2025-05-07

基本信息

别名

Bruno-like protein 1、BRUNOL1、CAG repeat protein 4

+ [13]

简介

RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

关联

100 项与 CELF3 相关的临床结果

登录后查看更多信息

100 项与 CELF3 相关的转化医学

登录后查看更多信息

0 项与 CELF3 相关的专利（医药）

登录后查看更多信息

250

项与 CELF3 相关的文献（医药）

2024-07-01·Plant Cell Reports

Unraveling the genetic basis of quantitative resistance to diseases in tomato: a meta-QTL analysis and mining of transcript profiles

Article

作者: Taheri, Ayat ; Osdaghi, Ebrahim ; Taghavi, S Mohsen ; Foolad, Majid R ; Khojasteh, Moein ; Chen, Gongyou ; Rahmanzadeh, Asma ; Darzi Ramandi, Hadi

KEY MESSAGEWhole-genome QTL mining and meta-analysis in tomato for resistance to bacterial and fungal diseases identified 73 meta-QTL regions with significantly refined/reduced confidence intervals. Tomato production is affected by a range of biotic stressors, causing yield losses and quality reductions. While sources of genetic resistance to many tomato diseases have been identified and characterized, stability of the resistance genes or quantitative trait loci (QTLs) across the resources has not been determined. Here, we examined 491 QTLs previously reported for resistance to tomato diseases in 40 independent studies and 54 unique mapping populations. We identified 29 meta-QTLs (MQTLs) for resistance to bacterial pathogens and 44 MQTLs for resistance to fungal pathogens, and were able to reduce the average confidence interval (CI) of the QTLs by 4.1-fold and 6.7-fold, respectively, compared to the average CI of the original QTLs. The corresponding physical length of the CIs of MQTLs ranged from 56 kb to 6.37 Mb, with a median of 921 kb, of which 27% had a CI lower than 500 kb and 53% had a CI lower than 1 Mb. Comparison of defense responses between tomato and Arabidopsis highlighted 73 orthologous genes in the MQTL regions, which were putatively determined to be involved in defense against bacterial and fungal diseases. Intriguingly, multiple genes were identified in some MQTL regions that are implicated in plant defense responses, including PR-P2, NDR1, PDF1.2, Pip1, SNI1, PTI5, NSL1, DND1, CAD1, SlACO, DAD1, SlPAL, Ph-3, EDS5/SID1, CHI-B/PR-3, Ph-5, ETR1, WRKY29, and WRKY25. Further, we identified a number of candidate resistance genes in the MQTL regions that can be useful for both marker/gene-assisted breeding as well as cloning and genetic transformation.

2024-03-01·Food Chemistry: X

Effect of EVA film and chitosan coating on quality and physicochemical characteristics of mango fruit during postharvest storage

Article

作者: Huang, Yumi ; Wang, Qing ; Pang, Xi ; Ali Shad, Munsif ; Xiao, Naiyu ; Feng, Bihong

Mango (Mangifera indica L.) is a major tropical fruit, but a short postharvest life hampers marketing. The objective of this work is to assess the influence of a novel nanocomposite poly (ethylene-co-vinyl acetate) (EVA) film and Chitosan (CTS) affect on mango postharvest quality while stored at 20 °C. The results showed that the film coating treatment reduced the decay rate and weight loss of mangoes, maintaining good postharvest quality of mango fruit. The film coating treatment increased the antioxidant capacity of mangoes by inhibiting PPO activity and increasing the activity of antioxidant enzymes. ACS, ACO, and ethylene release were all suppressed, as well as the expression of the ethylene receptors genes ETR1, ETR2, and ERS2, thus delaying mango aging. After harvest, the EVA treatment was superior to the CTS treatment in mango preservation.

2023-10-01·Journal of Comparative Neurology

Members of the CUGBP Elav‐like family of RNA‐binding proteins are expressed in distinct populations of primary sensory neurons

Article

作者: Mueth, Madison ; Harrison, Benjamin J. ; Reimonn, Thomas M. ; Ward, Patricia Jillian ; Molliver, Derek C. ; Grlickova‐Duzevik, Eliza ; Neufeld, Peter ; McGrath‐Conwell, Aidan ; Tian, Tina ; Owyoung, Jordan ; Michael, Merilla

AbstractPrimary sensory dorsal root ganglia (DRG) neurons are diverse, with distinct populations that respond to specific stimuli. Previously, we observed that functionally distinct populations of DRG neurons express mRNA transcript variants with different 3′ untranslated regions (3′UTRs). 3′UTRs harbor binding sites for interaction with RNA‐binding proteins (RBPs) for transporting mRNAs to subcellular domains, modulating transcript stability, and regulating the rate of translation. In the current study, analysis of publicly available single‐cell RNA‐sequencing data generated from adult mice revealed that 17 3′UTR‐binding RBPs were enriched in specific populations of DRG neurons. This included four members of the CUG triplet repeat (CUGBP) Elav‐like family (CELF): CELF2 and CELF4 were enriched in peptidergic, CELF6 in both peptidergic and nonpeptidergic, and CELF3 in tyrosine hydroxylase‐expressing neurons. Immunofluorescence studies confirmed that 60% of CELF4+ neurons are small‐diameter C fibers and 33% medium‐diameter myelinated (likely Aδ) fibers and showed that CELF4 is distributed to peripheral termini. Coexpression analyses using transcriptomic data and immunofluorescence revealed that CELF4 is enriched in nociceptive neurons that express GFRA3, CGRP, and the capsaicin receptor TRPV1. Reanalysis of published transcriptomic data from macaque DRG revealed a highly similar distribution of CELF members, and reanalysis of single‐nucleus RNA‐sequencing data derived from mouse and rat DRG after sciatic injury revealed differential expression of CELFs in specific populations of sensory neurons. We propose that CELF RBPs may regulate the fate of mRNAs in populations of nociceptors, and may play a role in pain and/or neuronal regeneration following nerve injury.

分析

对领域进行一次全面的分析。

或

查看完整样例数据

提出任何生物医药研究问题

让每一步生物医药决策都精准制胜

基于十亿级生物数据与全球情报的精准 AI，赋能早期药物发现

立即开始免费试用!

智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。

立即接入生物医药数据包

智慧芽新药库数据也通过智慧芽开放平台，以MCP或API服务形式对外开放。立即使用我们的MCP服务定制您的LLM智能体。