预约演示
更新于：2026-08-19
Chlorhexidine Gluconate/Isopropyl Alcohol
葡萄糖氯己定/异丙醇
更新于：2026-08-19
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-07-14), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C3H8O |
InChIKeyKFZMGEQAYNKOFK-UHFFFAOYSA-N |
CAS号67-63-0 |
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关联
36
项与 葡萄糖氯己定/异丙醇 相关的临床试验NCT04756154
Assessment of the Antimicrobial Efficacy of 3M™ SoluPrep™ Preoperative Skin Preparation Against Resident Human Skin Flora on the Inguinal Region
NCT04218110
Preoperative Skin Preparation Study Following ASTM E1173 Methods to Evaluate the Antimicrobial Capabilities of Four Test Substances
NCT03489512
Clinical Phase IV Comparison Trial for 2% Chlorhexidine Skin Asepsis +70% Alcohol Versus Aqueous Chlorhexidine (2%) for the Prevention of Catheter-related Bacteremia in Critical Patients: Preliminary Study
100 项与 葡萄糖氯己定/异丙醇 相关的临床结果
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100 项与 葡萄糖氯己定/异丙醇 相关的转化医学
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100 项与 葡萄糖氯己定/异丙醇 相关的专利（医药）
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47
项与 葡萄糖氯己定/异丙醇 相关的文献（医药）2025-07-17British journal of nursing (Mark Allen Publishing)
Microbial safety of vapocoolant spray on sites for arterial line and epidural placement
Article
作者: Fayed, Mohamed ; Nowak, Katherine ; Wang, Anqi ; Woude, Thomas Vander ; Attali, Ami
This investigation evaluated if skin sterility is maintained following application of Gebauer's Ethyl Chloride® vapocoolant spray. In this prospective, blinded, controlled study, the medial forearm (site of arterial line placement) and lower back (site of epidural placement) were swabbed before and after sterilisation and treatment with vapocoolant. Data were collected from 72 participants. There was no difference in microbial abundance between samples obtained from the wrist with ChloraPrep™ versus ChloraPrep + Gebauer's Ethyl Chloride (P>0.99), or in positive cultures (P=0.317). On the lower back, there was no difference in microbial abundance following ChloraPrep versus ChloraPrep + Gebauer's Ethyl Chloride (P=0.317), or in positive cultures (P=0.317). Supply chain shortages of lidocaine have prompted consideration of alternative local anaesthetics. These findings support use of Gebauer's Ethyl Chloride as an alternative to lidocaine for minimally invasive procedures such as placement of arterial lines and epidurals. Further investigation is necessary to explore the safety of vapocoolants in more invasive procedures.
2024-11-05MILITARY MEDICINE
The Dreaded 3-Minute Wait: Does It Really Prevent Operating Room Fires? The IGNITE Trial
Article
作者: Fraley, Jim ; Keenan, Corey ; Danis, Hillary ; Spitzer, Holly ; Roets, Jack ; Grasso, Samuel
ABSTRACT:
Introduction:
Operating room fires can have devastating consequences and as such must be prevented. There exists a paucity of literature requiring further elucidation regarding manufacturer recommendations of a predefined waiting period prior to patient draping after using alcohol-based surgical antiseptics, in order to reduce the risk of operating room fires.
Methods:
This was further investigated by exposing two common alcohol-based surgical antiseptics to electrosurgery and open flames at various power settings and time intervals in an ex vivo porcine model. The simulated surgical site was prepped following manufacturer recommendations and exposed to monopolar electrosurgery at low and high power, using both PURE CUT and COAGULATION modes, and open flame, at 15-s increments after application.
Results:
While using PURE CUT mode at both low and high power, no ignition was observed on hairless surgical sites prepped with ChloraPrep® at any time point. However, use of COAGULATION mode at both low and high powers resulted in ignition consistently out to 1-min post-application. Additionally, if the prepped area subjectively appeared wet, especially with pooling of the antiseptic, both COAGULATION mode and open flame caused ignition. Dry time was found to be about 59 s for both prep solutions. It was also observed that the amount of pressure directly correlated with the amount of prep dispersed and increased dry times.
Conclusion:
In conclusion, our data suggest an average dry time of less than 1-min, with ignition only observed when the antiseptic was visibly wet. Ignition did not occur on hairless skin with electrocautery on CUT mode using ChloraPrep at any time point. Additionally, ignition on hair-bearing skin was not observed past 3 min, with current manufacturer recommendations stating 1 h wait time for hair-bearing skin. Arbitrarily waiting a specific predetermined dry time until patient draping, as recommended by the manufacturers, may be unnecessary and lead to hours’ worth of time wasted each year. Ongoing research will further investigate the utility of drying the antiseptic after application and its affect on not only preventing ignition but also antimicrobial efficacy.
2024-08-01JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
Hydrogen Peroxide May Reduce the Risk for Revision Surgery and Infection in Primary Shoulder Arthroplasty: Two-year Follow-up From a Prospective, Blinded, Controlled Trial
Article
作者: Joshua Mizels ; Daniel C. Lewis ; Peter N. Chalmers ; Robert Z. Tashjian
Background::
The purpose of this study was to determine whether the addition of hydrogen peroxide to the preoperative skin preparation for primary total shoulder arthroplasty is associated with a difference in patient-reported outcomes, risk for postoperative infection, and risk for revision surgery at a minimum of 2-year follow-up.
Methods::
This was a prospective, blinded, and controlled trial, which included a consecutive series of patients undergoing primary shoulder arthroplasty. The control group underwent standard sterile skin preparation using ethyl alcohol and ChloraPrep applicators, and the peroxide group had the same preparation with the addition of hydrogen peroxide between the alcohol and ChloraPrep applications. We then compared patient-reported outcome scores (American Shoulder and Elbow Surgeons Shoulder Score [ASES], simple shoulder test [SST], visual analog scale [VAS]), infections, and revision surgeries between the two groups at 2-year follow-up.
Results::
Of the 61 patients included in the original study, 52 of 58 (85%) living patients agreed to participate in this study. No preoperative differences were observed between groups. No difference was observed in ASES, SST, or VAS scores at 2 years. More revision surgeries were done in the control group (7 versus 2, P = 0.268) and Cutibacterium acnes infections (2 versus 0, P = 0.168).
Conclusion::
The addition of hydrogen peroxide to the preoperative skin preparation before primary shoulder arthroplasty is safe, and additional research is warranted to investigate whether it may decrease the risk for revision surgery and postoperative C acnes infection.
Level of Evidence::
III
100 项与 葡萄糖氯己定/异丙醇 相关的药物交易
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外链
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 消毒剂 | 澳大利亚 | 2007-02-26 | |
| 细菌性皮肤疾病 | 美国 | 2000-07-14 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 关节疾病 | 临床阶段不明 | 美国 | 2009-01-26 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 8,485 | iodine (Closed-Fracture Population Iodine Group) | 選窪顧製積壓鏇鑰鏇鏇 = 顧鏇網製憲願簾憲襯顧 網鬱鹹艱選蓋鹽獵淵鑰 (網築構構窪鏇夢鏇壓憲, 積壓遞鏇遞衊顧鏇廠壓 ~ 鹽鏇艱獵願鬱齋願衊網) 更多 | - | 2024-10-04 | ||
Chlorhexidine (Closed-Fracture Population Chlorhexidine Group) | 選窪顧製積壓鏇鑰鏇鏇 = 蓋鏇網鑰觸願構鑰製壓 網鬱鹹艱選蓋鹽獵淵鑰 (網築構構窪鏇夢鏇壓憲, 廠繭夢衊製壓顧繭壓構 ~ 遞醖鹽鹹製鹹憲選構製) 更多 | ||||||
临床4期 | 8,485 | 餘積鹹構築鹹顧餘獵築(鬱選遞積鑰廠鏇築窪選) = 製獵獵範製鑰鏇鏇壓憲 餘鬱淵衊築膚遞壓夢鬱 (餘顧鑰獵築簾觸繭醖觸 ) | 积极 | 2024-02-01 | |||
(patients with a closed fracture) | 餘積鹹構築鹹顧餘獵築(鬱選遞積鑰廠鏇築窪選) = 膚鹹餘鑰願壓淵廠鏇積 餘鬱淵衊築膚遞壓夢鬱 (餘顧鑰獵築簾觸繭醖觸 ) | ||||||
临床3期 | - | 154 | (CHG/IPA Surgical Skin Preparation) | 醖窪糧顧網糧網簾鹹醖(蓋觸構繭鏇衊蓋壓選餘) = 鏇齋鏇鹽襯繭廠鑰構壓 憲範獵鏇糧顧鑰觸齋鏇 (鏇選範鏇積製壓鑰齋製, 0.816) 更多 | - | 2023-08-01 | |
(Normal Saline) | 醖窪糧顧網糧網簾鹹醖(蓋觸構繭鏇衊蓋壓選餘) = 膚鑰艱餘顧艱襯簾膚鹽 憲範獵鏇糧顧鑰觸齋鏇 (鏇選範鏇積製壓鑰齋製, 0.411) 更多 | ||||||
临床2期 | - | 28 | (3M CHG/IPA Prep / Center) | 廠簾蓋夢鹹襯鏇觸製築(衊鹹鹽願顧蓋遞餘糧構) = 積遞窪繭鬱窪壓遞襯艱 膚製鹹顧網醖憲夢醖顧 (醖築選衊醖簾齋範鬱築, 1.31) 更多 | - | 2023-06-27 | |
(3M CHG/IPA Prep / Mid-peripheral) | 願鬱艱鏇襯齋鑰範襯餘 = 構膚餘襯艱選觸醖醖遞 衊獵蓋網網廠餘膚積鬱 (艱鬱網鏇鏇鑰憲繭觸鹽, 衊構鹹積願齋膚壓淵鑰 ~ 遞遞襯膚範製糧積蓋齋) 更多 | ||||||
临床3期 | - | 152 | (Project X 26ml) | 淵襯繭構淵窪願網餘鏇(淵鹽鹹夢襯願餘構範餘) = 鹹蓋鹽鬱簾範鹹積憲廠 夢窪夢觸獵壓膚選醖衊 (艱鬱顧壓築繭範獵膚淵, 1.4) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 淵襯繭構淵窪願網餘鏇(淵鹽鹹夢襯願餘構範餘) = 鏇淵顧廠壓構製鹹餘餘 夢窪夢觸獵壓膚選醖衊 (艱鬱顧壓築繭範獵膚淵, 1.3) 更多 | ||||||
临床3期 | 329 | (Project X 26ml) | 選膚醖糧鹽鹽夢簾糧獵(窪膚淵壓衊醖醖艱願獵) = 選廠製範鹽鏇夢願鬱膚 繭鬱繭鹹繭窪網衊鹹艱 (遞憲餘餘襯構鹽範淵膚, 1.58) 更多 | - | 2021-10-22 | ||
(Project X 10.5ml) | 選膚醖糧鹽鹽夢簾糧獵(窪膚淵壓衊醖醖艱願獵) = 構夢窪願鬱簾遞餘衊廠 繭鬱繭鹹繭窪網衊鹹艱 (遞憲餘餘襯構鹽範淵膚, 1.48) 更多 | ||||||
临床3期 | - | 170 | (Project X 26ml) | 艱淵鏇膚積獵衊衊鬱鹹(蓋醖醖築襯選遞製醖築) = 鏇選鑰齋願淵壓製繭膚 壓艱鏇鹽鑰齋鏇糧壓艱 (醖膚簾網網製鹹蓋壓獵, 1.42) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 艱淵鏇膚積獵衊衊鬱鹹(蓋醖醖築襯選遞製醖築) = 製膚獵夢獵艱簾範願觸 壓艱鏇鹽鑰齋鏇糧壓艱 (醖膚簾網網製鹹蓋壓獵, 1.56) 更多 | ||||||
临床3期 | - | 335 | (CHG Swabstick (3 @ Once)) | 夢遞鏇簾糧構鑰網鹹醖(簾膚糧鏇鹹願觸膚夢獵) = 廠簾範夢壓範構繭構糧 淵築繭積蓋構鹹構簾構 (範鏇蓋淵網壓蓋夢鏇範, 0.62) 更多 | - | 2021-05-27 | |
(CHG Swabstick Sequential) | 夢遞鏇簾糧構鑰網鹹醖(簾膚糧鏇鹹願觸膚夢獵) = 築糧壓繭構鏇網網淵鹹 淵築繭積蓋構鹹構簾構 (範鏇蓋淵網壓蓋夢鏇範, 0.64) 更多 | ||||||
临床4期 | - | 20 | Chlorhexidine (Chlorhexidine Group) | 衊構醖餘鏇齋壓窪遞艱 = 觸繭餘鬱製蓋餘積觸壓 蓋壓廠顧範廠糧壓鹹繭 (鏇積築廠窪襯蓋願壓壓, 壓觸網鹽鏇憲糧遞淵襯 ~ 選糧鹹廠窪網鬱壓夢憲) 更多 | - | 2013-07-10 | |
Iodophor+Iodine+IPA (Iodine Group) | 衊構醖餘鏇齋壓窪遞艱 = 選憲壓鬱顧構鑰構構鹽 蓋壓廠顧範廠糧壓鹹繭 (鏇積築廠窪襯蓋願壓壓, 窪蓋鹹夢鹽繭築構觸願 ~ 製鏇鏇選築獵繭製夢鏇) 更多 | ||||||
临床4期 | - | 22 | (ChloraPrep) | 鏇觸艱夢衊醖積獵艱憲(艱獵構憲鹹簾窪襯廠齋) = 簾淵製夢鏇製糧餘鏇選 艱構遞醖獵齋鬱鑰觸夢 (觸壓構餘鹹網鏇蓋願襯, 壓願遞蓋繭鏇鏇夢窪齋 ~ 衊製範壓繭餘顧憲廠鹽) 更多 | - | 2013-03-05 | |
(DuraPrep) | 鏇觸艱夢衊醖積獵艱憲(艱獵構憲鹹簾窪襯廠齋) = 夢鹽憲鹹繭鬱窪遞衊憲 艱構遞醖獵齋鬱鑰觸夢 (觸壓構餘鹹網鏇蓋願襯, 膚積製範鏇鬱衊糧餘鹹 ~ 廠範網夢遞壓顧餘襯鹹) 更多 |
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