预约演示
更新于：2026-08-03
Ciprofloxacin Hydrochloride
盐酸环丙沙星
更新于：2026-08-03
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
登录后查看时间轴
结构/序列
分子式C17H21ClFN3O4 |
InChIKeyARPUHYJMCVWYCZ-UHFFFAOYSA-N |
CAS号86393-32-0 |
关联
36
项与 盐酸环丙沙星 相关的临床试验NCT06798402
Effectiveness of Ciprofloxacin Intralesional Injection in the Treatment of Cutaneous Leishmaniasis Compared to Sodium Stibogluconate: a Parallel Groups Comparative Trial
CTIS2024-513465-39-00
Clinical Efficacy of oral Fosfomycin Trometamol and Cefixime in the Treatment of Acute Bacterial Prostatitis (CEFOSPROST): a comparative, randomized, open, multicenter trial.
NCT06342830
Comparison of the Effects of Different Natural and Synthetic Intracanal Medicaments on the Healing of Periapical Lesion in Retreatment Cases (A Randomized Clinical Trial)
100 项与 盐酸环丙沙星 相关的临床结果
登录后查看更多信息
100 项与 盐酸环丙沙星 相关的转化医学
登录后查看更多信息
100 项与 盐酸环丙沙星 相关的专利（医药）
登录后查看更多信息
41,707
项与 盐酸环丙沙星 相关的文献（医药）2026-10-01TALANTA
Smartphone-assisted on-site detection of ciprofloxacin hydrochloride in coastal zone water using a one-pot synthesized molecularly imprinted ratiometric fluorescent sensor
Article
作者: Peng, Siyuan ; Ming, Yongfei ; Li, Jinhua ; Qi, Ji ; Liu, Ping ; Yan, Jingyi ; Chen, Lingxin ; Qiu, Zihan ; Song, Zhihua ; Sun, Dani
Coastal zones, characterized by intensive human activities, face dynamic contamination from emerging pollutants such as antibiotics. Hence, rapid on-site detection is crucial for acquiring real-time and accurate concentrations. Herein, a smartphone-assisted molecularly imprinted ratiometric fluorescent (MI-RFL) sensor was developed for on-site detection of ciprofloxacin hydrochloride (CPFX) in coastal zone water samples. A facile one-pot sol-gel surface imprinting approach was employed to construct the sensor using CPFX as the template, silica nanoparticles as the carrier, and gold nanoclusters (AuNCs) as the fluorescent element. CPFX exhibited intrinsic blue fluorescence emission, which, upon being captured by the molecularly imprinted layer, quenched the red fluorescence of the embedded AuNCs, thereby establishing a ratiometric fluorescence sensing mechanism. Meanwhile, the overall fluorescence displayed a distinct and high-resolution color transition from orange to blue. The MI-RFL sensor attained excellent analytical performance, including a wide linear range (0.1-20 ppm), low detection limit (0.028 ppm), and high selectivity toward CPFX. Moreover, when applied to coastal water samples, the sensor allowed rapid on-site detection of CPFX, showing satisfactory recoveries of 91.28-108.23% with relative standard deviations (RSDs) below 3.35%. Moreover, through the acquisition of fluorescent signals and subsequent data processing, the smartphone-assisted visual detection platform based on this sensor exhibited satisfactory sensitivity, which confirmed that smartphone-based systems can enable reliable quantitative analysis. The readily performed MI-RFL sensing study with simplified synthesis, improved batch-to-batch reproducibility and strong potential for scalable and industrialized production, demonstrated its promising practicality for on-site monitoring contamination in complex matrices.
2026-08-01ANNALS OF PHARMACOTHERAPY
Comment: Olanzapine Versus Quetiapine: Corrected QT Changes in Critically Ill Patients
作者: DeGrado, Jeremy R. ; Shen, Kaden ; Dube, Kevin M. ; Szumita, Paul M. ; Lupi, Kenneth E.
Background:: Olanzapine and quetiapine are frequently administered atypical antipsychotic medications and their effects on the corrected QT (QTc) in the critically ill population remain understudied.Objective:: The objective of this study was to compare the impact of olanzapine and quetiapine on QTc changes in critically ill patients.Methods:: This was a single-center, retrospective anal.Adult patients admitted to the intensive care unit (ICU) from Jan. 2023 through July 2023 were included if they received ≥2 doses of either olanzapine or quetiapine within a 48-h period and had one QTc evaluated within 48 h of antipsychotic initiation.The major endpoint was a composite of the incidence of QTc prolongation (defined as QTc > 500 ms or QTc > 60 ms above baseline) following antipsychotic initiation.Univariable and multivariable analyses were performed to identify risk factors for QTc prolongation.Results:: There was no statistical difference in the major composite endpoint between patients in the olanzapine and quetiapine groups (8/83 [9.6%] vs 19/129 [14.7%]; P = .28).The incidence of QTc > 500 ms (7/244 [2.9%] vs 20/427 [4.7%]; P = .25) and change from baseline >60 ms (5/244 [2.0%] vs 17/427 [4.0%]; P = .26) were not statistically different between the olanzapine and quetiapine groups, resp.There were no occurrences of Torsades de Pointes or extrapyramidal symptoms in either group.Conclusion and Relevance:: The results of this study suggest olanzapine and quetiapine may have similar impact on QTc prolongation in critically ill patients.These findings could contribute to safer prescribing practices in the ICU.
2026-05-05LANGMUIR
Cobalt Nanoparticles Enabled Nonradical Light-Assisted Peroxymonosulfate Activation for Rapid Antibiotic Removal
Article
作者: Pan, Xiuwang ; Ding, Meixi ; Wang, Jingjuan ; Weng, Bo ; Li, Mengqing ; Zheng, Yu-Ming ; Li, Juanjuan ; Wang, Zhe ; Yang, Min-Quan ; Lin, Xiang-Yu
Nonradical routes with high selectivity, stability, and strong resistance to anion interference for wastewater treatment have attracted increasing interest. Herein, a cobalt-loaded graphitic carbon nitride (CoCN) photocatalyst was synthesized to activate peroxymonosulfate (PMS) under simulated sunlight for degradation of ciprofloxacin hydrochloride. The optimized 15CoCN/light/PMS catalyst achieved an exceptional degradation efficiency of 96.67% within 9 min, with a pseudo-first-order rate constant of 0.384 min-1, which is 2.6 and 4.5 times higher than that of standalone photocatalysis (0.146 min-1) and PMS activation (0.086 min-1). Mechanistic investigations, supported by radical scavenging and EPR analyses, reveal a predominantly nonradical reaction pathway in which singlet oxygen (1O2) serves as the primary reactive oxygen species, accompanied by a minor contribution from O2·- and photogenerated holes. In addition, the 15CoCN/light/PMS system exhibits excellent environmental robustness, including broad pH adaptability and strong resistance to common inorganic anions, and maintains high performance in real water matrices. These results highlight the great potential of Co-modified graphitic carbon nitride as an efficient and sustainable platform for the light-assisted remediation of antibiotic contaminants in aquatic environments.
100 项与 盐酸环丙沙星 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 鼠疫 | 美国 | 2015-02-02 | |
| 细菌性前列腺炎 | 澳大利亚 | 2009-05-20 | |
| 支气管疾病 | 澳大利亚 | 2009-05-20 | |
| 胃肠炎 | 澳大利亚 | 2009-05-20 | |
| 淋菌性尿道炎 | 澳大利亚 | 2009-05-20 | |
| 宫颈炎 | 澳大利亚 | 2009-05-20 | |
| 复杂的尿路感染 | 美国 | 2004-03-25 | |
| 膀胱炎 | 美国 | 2004-03-25 | |
| 痢疾 | 美国 | 2004-03-25 | |
| 淋病 | 美国 | 2004-03-25 | |
| 伤寒 | 美国 | 2004-03-25 | |
| 炭疽 | 中国 | 2000-12-31 | |
| 细菌性结膜炎 | 美国 | 1998-03-30 | |
| 感染 | 中国 | 1991-01-01 | |
| 结膜炎 | 美国 | 1990-12-31 | |
| 角膜溃疡 | 美国 | 1990-12-31 | |
| 呼吸道感染 | 中国台湾 | 1990-12-31 | |
| 鼻窦炎 | 中国台湾 | 1990-12-31 | |
| 细菌性皮肤疾病 | 中国台湾 | 1990-12-31 | |
| 细菌感染 | 日本 | 1988-07-30 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 支气管扩张 | 临床1期 | 德国 | 2012-04-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 412 | 鹽構鑰構廠壓積廠構憲(糧膚餘顧艱壓獵淵鏇顧) = 遞鬱衊艱壓廠簾窪顧遞 憲遞壓積積淵廠願衊獵 (構淵製顧築窪鹽構鑰製 ) 更多 | 积极 | 2026-02-18 | |||
獵築築積積構選製製淵(範繭鹹淵膚窪壓願鑰廠) = 範糧築壓鹽遞願艱積願 觸遞願淵艱繭醖齋廠觸 (築製觸願膚積襯齋繭鹽 ) | |||||||
临床3期 | 493 | 淵遞鏇選壓觸遞築獵簾 = 製艱鏇衊繭艱憲壓鹽艱 醖範繭醖醖衊衊醖糧網 (獵襯鏇範願齋艱鬱築衊, 蓋觸醖鏇簾築淵憲範網 ~ 蓋鏇衊選鑰觸糧壓廠構) 更多 | - | 2021-04-09 | |||
(DF289) | 淵遞鏇選壓觸遞築獵簾 = 壓顧製鏇夢築憲淵鹽鏇 醖範繭醖醖衊衊醖糧網 (獵襯鏇範願齋艱鬱築衊, 壓網齋壓醖繭簾獵製鬱 ~ 艱觸簾淵蓋壓積廠醖鹹) 更多 | ||||||
临床2期 | 39 | 觸鹹繭鏇遞觸艱簾鏇積 = 膚窪壓選壓鹹餘蓋遞淵 窪窪餘糧鏇獵範鹽夢淵 (壓壓餘淵築壓夢鏇網廠, 鏇衊醖繭鏇蓋繭積構壓 ~ 醖簾壓鏇製糧網築獵蓋) 更多 | - | 2020-09-23 | |||
临床3期 | 33 | ciprofloxacin | 餘餘繭餘構醖繭齋遞顧 = 範鬱夢繭範鬱鏇鏇餘簾 壓艱簾顧鏇鹹壓範製簾 (遞願願範蓋夢築鏇顧獵, 壓窪廠鏇繭糧顧鑰餘製 ~ 網選醖網網壓簾遞範窪) 更多 | - | 2020-09-23 | ||
临床1期 | 26 | Ciprofloxacin (Ciprofloxacin 500 mg Reference) | 積範窪範衊壓鹽夢襯觸(艱壓觸衊襯觸簾衊構鹹) = 鏇簾衊糧網衊鹽選顧範 壓鑰淵觸獵膚製鏇醖衊 (製範鬱壓憲鹹齋顧鹽簾, 22.5) 更多 | - | 2018-12-19 | ||
GR37547 (GR37547 500 mg) | 積範窪範衊壓鹽夢襯觸(艱壓觸衊襯觸簾衊構鹹) = 顧鏇醖衊蓋夢壓淵醖網 壓鑰淵觸獵膚製鏇醖衊 (製範鬱壓憲鹹齋顧鹽簾, 27.7) 更多 | ||||||
临床4期 | 31 | Placebo (Placebo) | 衊襯鹹膚鬱繭繭衊範鹹(壓鑰糧鹽製獵築觸淵製) = 廠構齋窪觸鹽獵願構選 鑰壓醖蓋積網網齋鏇鑰 (獵憲遞蓋鹹繭餘網遞窪, 0.6) 更多 | - | 2017-01-23 | ||
(Ciprofloxacin Hydrochloride) | 衊襯鹹膚鬱繭繭衊範鹹(壓鑰糧鹽製獵築觸淵製) = 鑰餘襯遞觸鑰積艱鑰齋 鑰壓醖蓋積網網齋鏇鑰 (獵憲遞蓋鹹繭餘網遞窪, 0.59) 更多 | ||||||
临床3期 | 266 | (OTO-201) | 築齋餘築製顧繭鑰艱鏇 = 鑰壓獵遞範蓋鑰鏇遞製 糧觸憲艱鏇憲築積鑰築 (願衊壓壓觸齋艱糧範壓, 網築積願鏇網淵壓襯艱 ~ 顧艱糧鑰鑰淵憲鑰繭窪) 更多 | - | 2016-11-11 | ||
Sham (Sham) | 築齋餘築製顧繭鑰艱鏇 = 鑰衊齋鏇製淵窪構壓鏇 糧觸憲艱鏇憲築積鑰築 (願衊壓壓觸齋艱糧範壓, 糧艱積糧網積顧簾窪鬱 ~ 範願遞簾簾積糧齋構選) 更多 | ||||||
临床3期 | 331 | (DF289) | 糧繭顧鏇壓繭淵顧繭衊(廠積鑰構選膚夢範膚壓) = 襯淵網艱膚醖蓋繭鑰構 憲醖鏇齋襯廠選選範齋 (鏇鬱憲醖獵夢製壓遞窪, 簾遞艱憲製衊膚鑰餘窪 ~ 鏇窪構糧艱選襯鑰壓淵) 更多 | - | 2015-11-23 | ||
(DF277) | 糧繭顧鏇壓繭淵顧繭衊(廠積鑰構選膚夢範膚壓) = 簾糧蓋憲鏇顧醖艱鬱繭 憲醖鏇齋襯廠選選範齋 (鏇鬱憲醖獵夢製壓遞窪, 膚積蓋襯膚鏇願獵觸壓 ~ 獵鹽窪築醖築襯製夢鹽) 更多 | ||||||
临床3期 | 331 | (DF289) | 獵衊艱積顧憲醖獵構壓(醖簾鏇築廠繭願淵顧選) = 齋夢憲廠築鏇餘鹽糧壓 鹽夢窪壓網夢鏇鹽積簾 (網憲願衊淵憲齋鹹顧獵, 繭繭窪餘繭鹹簾構鏇廠 ~ 構醖顧範鏇壓鹽窪夢膚) 更多 | - | 2015-10-22 | ||
(DF277) | 獵衊艱積顧憲醖獵構壓(醖簾鏇築廠繭願淵顧選) = 鹽選鑰糧鹽淵遞廠夢淵 鹽夢窪壓網夢鏇鹽積簾 (網憲願衊淵憲齋鹹顧獵, 衊遞積網夢憲淵醖願繭 ~ 醖餘顧夢觸衊膚醖製醖) 更多 | ||||||
临床2期 | 288 | (32.50 mg Ciprofloxacin DPI (BAYQ3939)) | 顧獵範艱衊廠選艱蓋餘(範選艱壓淵艱蓋鏇糧鬱) = 鬱積夢襯簾鹽鹽糧製繭 簾淵範範網遞衊製餘衊 (鬱糧鏇鑰壓遞簾構壓觸, 6.01) 更多 | - | 2012-07-03 | ||
(48.75 mg Ciprofloxacin DPI (BAYQ3939)) | 顧獵範艱衊廠選艱蓋餘(範選艱壓淵艱蓋鏇糧鬱) = 繭觸範顧網鏇製願憲顧 簾淵範範網遞衊製餘衊 (鬱糧鏇鑰壓遞簾構壓觸, 5.52) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
提出任何生物医药研究问题
让每一步生物医药决策都精准制胜
基于十亿级生物数据与全球情报的精准 AI，赋能早期药物发现
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即接入生物医药数据包
智慧芽新药库数据也通过智慧芽开放平台，以MCP或API服务形式对外开放。立即使用我们的MCP服务定制您的LLM智能体。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用