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更新于：2025-05-07

NFYA

更新于：2025-05-07

基本信息

别名

CAAT box DNA-binding protein subunit A、CBF-B、HAP2

+ [4]

简介

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1.

关联

项与 NFYA 相关的药物

GWL-78

靶点

NFYA

作用机制

NFYA modulators

在研机构-

原研机构

ADC Products (UK) Ltd.

在研适应症-

非在研适应症

肿瘤

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

ELB-21

靶点

NFYA

作用机制

NFYA inhibitors

在研机构-

原研机构

ADC Products (UK) Ltd.

在研适应症-

非在研适应症

细菌感染

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 NFYA 相关的临床结果

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100 项与 NFYA 相关的转化医学

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0 项与 NFYA 相关的专利（医药）

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1,207

项与 NFYA 相关的文献（医药）

2025-12-31·Plant Signaling & Behavior

Genome-wide identification and analysis of the NF-Y transcription factor family reveal its potential roles in tobacco ( Nicotiana tabacum L.)

Article

作者: Mao, Jingjing ; Wang, Baojian ; Cheng, Fanrui ; Sun, Jinhao ; Li, Shaopeng ; Song, Wenting ; Wang, Dawei ; Chao, Jiangtao ; Tian, Zhen ; Xue, Luyao ; Fu, Jincun ; Yue, Xiujiang

Nuclear Factor Y (NF-Y) represents a group of transcription factors commonly present in higher eukaryotes, typically consisting of three subunits: NF-YA, NF-YB, and NF-YC. They play crucial roles in the embryonic development, photosynthesis, flowering, abiotic stress responses, and other essential processes in plants. To better understand the genome-wide NF-Y domain-containing proteins, the protein physicochemical properties, chromosomal localization, synteny, phylogenetic relationships, genomic structure, promoter cis-elements, and protein interaction network of NtNF-Ys in tobacco (Nicotiana tabacum L.) were systematically analyzed. In this study, we identified 58 NtNF-Ys in tobacco, respectively, and divided into three subfamilies corresponding to their phylogenetic relationships. Their tissue specificity and expression pattern analyses for leaf development, drought and saline-alkali stress, and ABA response were carried out using RNA-seq or qRT-PCR. These findings illuminate the role of NtNF-Ys in regulating plant leaf development, drought and saline-alkali stress tolerance, and ABA response. This study offers new insights to enhance our understanding of the roles of NtNF-Ys and identify potential genes involved in leaf development, as well as drought and saline-alkali stress tolerance of plants.

2025-12-31·Artificial Cells, Nanomedicine, and Biotechnology

Microvesicles and exosomes isolated from murine bone marrow-derived mesenchymal stromal cells primed with p38MAPK inhibitor differentially regulate hematopoietic stem cell function

Article

作者: Vaidya, Anuradha ; Budgude, Pallavi ; Kale, Vaijayanti

The signaling mechanisms active within mesenchymal stromal cells (MSCs) influence the composition of microvesicles (MVs) and exosomes (Exos) secreted by them. Previously, we showed that priming MSCs with a p38 pharmacological inhibitor (pMSCs) rejuvenates them and improves their ability to promote ex vivo hematopoietic stem cell (HSC) expansion. This study examined whether pMSCs exerted HSC-supportive ability via MVs (pMVs) and Exos (pExos). Our findings demonstrate distinct regulation of HSC fate by pMVs and pExos. pMVs promoted the expansion of long-term HSCs (LT-HSCs), distinguished by their robust self-renewal capacity and superior engraftment ability. In contrast, pExos facilitated expansion of short-term HSCs (ST-HSCs) with high proliferative and differentiation potential. Infusing a combination of pMVs- and pExos-expanded HSCs as a composite graft resulted in significantly higher HSC engraftment, emphasizing the synergistic interaction between LT- and ST-HSC populations. Gene expression studies, functional and phenotypic experiments showed that pMVs regulate HSC quiescence via the Egr1/Cdkn1a axis, while pExos control HSC proliferation via the Nfya/Cdkn1a axis. These findings provide insights into the molecular mechanisms underlying the differential regulation of HSC function by pMVs and pExos. It also proposes a composite graft strategy of using pMVs and pExos as "MSC-derived biologics" for improving the HSC transplantation success.

2025-12-31·GM Crops & Food

ZmNF-YB10 , a maize NF-Y transcription factor, positively regulates drought and salt stress response in Arabidopsis thaliana

Article

作者: Jiao, Peng ; Guan, Shuyan ; Wang, Yimeng ; Wang, Chunlai ; Shi, Ke ; Ma, Yiyong ; Wu, Chenyang ; Gao, Xiaoqi

Maize (Zea mays L.) is a major food and feed crop and an important raw material for energy, chemicals, and livestock. The NF-Y family of transcription factors in maize plays a crucial role in the regulation of plant development and response to environmental stress. In this study, we successfully cloned and characterized the maize NF-Y transcription factor gene ZmNF-YB10. We used bioinformatics, quantitative fluorescence PCR, and other techniques to analyze the basic properties of the gene, its tissue expression specificity, and its role in response to drought, salt, and other stresses. The results indicated that the gene was 1209 base pairs (bp) in length, with a coding sequence (CDS) region of 618 bp, encoding a polypeptide composed of 205 amino acid residues. This polypeptide has a theoretical isoelectric point of 5.85 and features a conserved structural domain unique to the NF-Y family. Quantitative fluorescence PCR results demonstrated that the ZmNF-YB10 gene was differentially upregulated under drought and salt stress treatments but exhibited a negatively regulated expression pattern under alkali and cold stress treatments. Transgenic Arabidopsis thaliana subjected to drought and salt stress in soil showed greener leaves than wild-type A. thaliana. In addition, the overexpression lines showed reduced levels of hydrogen peroxide (H₂O₂), superoxide (O^2-), and malondialdehyde (MDA) and increased activities of peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD). Western blot analysis revealed a distinct band at 21.8 kDa. Salt and drought tolerance analyses conducted in E. coli BL21 indicated a positive regulation. In yeast cells, ZmNF-YB10 exhibited a biological function that enhances salt and drought tolerance. Protein interactions were observed among the ZmNF-YB10, ZmNF-YC2, and ZmNF-YC4 genes. It is hypothesized that the ZmNF-YB10, ZmNF-YC2, and ZmNF-YC4 genes may play a role in the response to abiotic stresses, such as drought and salt tolerance, in maize.